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A more recent hypothesis postulates that high-dose folic acid redirects the active form of vitamin B12 in serum, i.e., holotranscobalamin, either toward the bone marrow to support reticulocyte synthesis that is induced by folic acid in B12-deficient patients, or into the urine in which it is excreted instead of being taken up and recycled into circulation through the kidneys (84)

Overall, there are just too many red flags here to take this study seriously

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Melatonin suppresses ILC2 function via NRF2 activation Whilst we found that melatonins immunosuppressive effects on ILC2s were glutathione dependent, the upstream mechanism linking melatonin to glutathione biosynthesis remained unclear

Remarkably, the same narrow dose range proves effective whether counteracting dopamine depletion, serotonin syndrome, glutamate excitotoxicity, or GABA tolerance