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(2024), using proteomic analysis and data from The Cancer Genome Atlas (TCGA), discovered that SHARPIN is upregulated in CRC tissues

doi: 10.1007/s10654-015-0090-x 168 MartinF.LindenT.KatschinskiD

Maintenance of both mitochondrial quantity and quality is strictly related to the conservation of an adequate concentration of several proteins, such as PGC-1, TFAM, mitochondrial cristae biogenesis protein optic atrophy 1 (Opa1), Drp1, Mitofusin 1 (Mfn1), Mitofusin 2 (Mfn2), mitochondrial fission protein 1 (FIS1), PINK1, Parkin, VDAC1, Bnip3, and Nix, reunited in the process of proteostasis (Moreira et al., 2017

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