This deficiency worsens oxidative stress and contributes to complications, including symptoms like fatigue
Mutations identified in patients with defective lipoic acid metabolism affect genes involved in the synthesis of iron-sulfur clusters and genes coding for lipoic acid synthetase ( LIAS ), lipoyl transferase 1 ( LIPT1 ), and dihydrolipoamide dehydrogenase (E3 component of -ketoacid dehydrogenase complexes
Thus, action on the patients biology cannot be limited to drugs, the level of efficacy of which is modest, but can include physical activity, personalized nutraceuticals based on biomarkers, and a specialized non-pharmacological medical intervention such as acupuncture, which one of the authors (A.G.B.) also uses routinely in psychiatric disorders as we shall see in the clinical case we present
Peptide started to sound like the future, the way "blockchain" did in 2017, when adding the word to a company's name could send its stock up
Taking glutathione before bed is a simple habit that can have a profound impact on your daily life