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Visual signs of freezing include cloudiness, ice crystals visible in the vial, or a change in the solution's clarity from its original transparent appearance

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In some cases, combining medications (like GLP-1 + metformin or an SGLT2 inhibitor) can offer added benefits

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Furthermore, several purine metabolites (UA, guanosine, or xanthine) are each significantly correlated with 5-hydroxyindoleacetic acid (5-HIAA) in healthy controls, but not in FENNS at baseline or 4-week after antipsychotic treatment