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4.3 Application of targeted Gln in combination with current antitumor therapies Radiotherapy, chemotherapy, targeted therapy, and immunotherapy are the primary therapeutic modalities in the modern clinical treatment of malignant tumors, offering hope to many cancer patients

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Dysbiosis during this transition underlies elevated ketosis risk: the decline of VFA-producing taxaincluding Ruminococcus , Prevotella , Selenomonas , and Succinivibrionaceaeimpairs propionate fermentation pathways and reduces gluconeogenic precursor supply, while the concurrent expansion of opportunistic taxa such as Mycoplasma and Saccharimonas further destabilizes ruminal homeostasis (Table 2), collectively contributing to hypoglycemia, excessive mobilization of body fat, and ketone accumulation, which compromise lactation, reproductive performance, and offspring health 47,55,56,57

doi: 10.1089/jmf.2016.3693 93 PercivalSS