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In the SURMOUNT-1 clinical trial, adults with obesity treated with tirzepatide 15 mg weekly for 72 weeks achieved a mean body weight reduction of 22.5%, with 63% of participants achieving 20% weight loss

Binding of insulin to its receptor (INSR) leads to phosphorylation of intracellular substrates, such as insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, and other signaling intermediates

In the other analyzed clinical trials, the supplementation protocols differed, mainly including at least a month of beta-alanine or carnosine intake from 800 mg to 2.5 g/day

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In cells, it helps transport fatty acids into the mitochondria, where they can be burned for energy