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Skaper SD, Facci L, Zusso M, Giusti P (2018) An inflammation-centric view of neurological disease: beyond the neuron

The topical application of THC, CBD, and HU-308 [247], dissolved in soybean oil, either as sole agents or in combination, resulted in a significant reduction in pain scores [248]

Systemic treatment with LPS induces depressive-like behaviors and increases the production of inducible nitric oxide synthase (iNOS), IL-1, TNF-, and GFAP in the hippocampus and cortex