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A letter to Clinical Toxicology from Shah, et al., at Carolinas Medical Center, recommended the antidote in very limited cases of severe acetaminophen toxicity, stating that they strongly believed that a single dose of fomepizole had a reasonable balance of potential benefit, safety, and cost to suggest its targeted use on a case-by-case basis until a randomized, controlled trial is performed

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-Grape Seed Extract contains natural compounds such as resveratrol and flavonoids with high functional antioxidant activity

Alcohol impairs its absorption and use in the body

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