Key reasons GLP-1s require heightened caution in eating disorder populations include: Appetite suppression that may reinforce restrictive behaviors Rapid or significant weight changes that can increase psychological distress Heightened focus on food intake, body cues, or weight-related outcomes Temporary behavioral changes that may mask symptoms rather than address underlying drivers Eating disorders are multifaceted mental health conditions that cannot be effectively treated through appetite or weight changes alone
Lifestyle plays a huge role in keeping the weight off for good
Without enough of it, foods may start tasting bland, creating a cycle of poor [food] intake, say Allidina
A Monte Carlo simulation says: we project a 40th-percentile outcome of 30% share retention, a median outcome of 45%, and a 90th-percentile outcome of 62%, with the full probability distribution shaped by our assumptions about competitor count, payer formulary decisions, and IRA negotiation outcomes
On the other hand, inducers increase P-450 activity by increasing enzyme production, or, in the case of CYP2E1, preventing degradation in the proteasome
