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10.1074/jbc.M210419200 332 TomkinsJ.DempsterS.BannerS

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Specifically, ATF-4 enhances stress resistance and promotes longevity in worms by upregulating the transsulfuration enzyme CTH-2, increasing hydrogen sulfide (H 2 S) production ( In mammalian cells, stress conditions lead to the upregulation of CHAC1 through the action of ATF4