access to tirzepatide Eli Lilly has launched new self-pay options for tirzepatide, introducing 7.5 mg and 10 mg single-dose vials for $499 through the Zepbound Self Pay Journey Program. This initiative, available exclusively via LillyDirect Zepbound Now Available Through LillyDirect:

The typical switching profile: Started Zepbound through insurance with a reasonable copay ($50 to $150) Insurance coverage changed (job change, plan renewal, formulary update) New copay jumped to $300 to $600 per month Patient called Costco to check cash price, found it over $1,000 Patient researched compounded alternatives and switched to FormBlends The second common pattern: Medicare patient, retired, fixed income Part D plan covers Zepbound with $400 to $500 specialty copay Cannot use Lilly savings card (Medicare exclusion) Annual Zepbound cost would be $4,800 to $6,000 Switches to compounded tirzepatide at $2,148 to $3,348 annually The third pattern: Self-employed or between jobs, no insurance Paying Costco cash price ($1,000+ per month) Cannot sustain $12,000+ annual cost Switches to compounded at $179 to $279 per month What we don't see: patients with stable commercial insurance and $25 copays switching to compounded

Nussinov et al., 2019a

Proteins Beef Lean ground meats Skinless poultry Shellfish Produce Apples Blueberries Banana Bell peppers Arugula Asparagus Grains Beans Brown rice Wild rice Eggs and Dairy Cottage cheese Feta cheese Ricotta cheese Greek yogurt Egg whites Egg substitutes Condiments Ketchup Teriyaki sauce Barbecue sauce Relish Drinks Oat milk Almond milk Coffee Tea How Much Should You Exercise on the Jenny Craig Diet

The monkeys were identified by shaving marks enabling the researchers to differentiate between semaglutide- and vehicle-treated monkeys

Br J BioMed Sci (2020) 77(4):196201