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Erastin was shown to induce ferroptosis in lung cancer A549 cells, accompanied by increased oxidative stress, lipid peroxidation, and decreased expression of E-cadherin and SLC7A11

Trading stability for new function may help to explain why evolved enzymes often have lower activity or specificity for their new functions than their WT starting points

GLP-1 agonists have shown direct benefits in slowing the progression of kidney disease , independent of their effects on blood sugar or weight [8, 9]

However, these studies did not solve the question of whether melatonin is beneficial or detrimental, an issue that will be discussed in the context of the peculiarities of the melatonergic system