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Study Design: Participants who achieved average 20.9% weight loss on tirzepatide over 36 weeks were randomized to either: Continue tirzepatide Switch to placebo Results at 88 Weeks (52 weeks after randomization): Continued Tirzepatide: Additional 5.5% weight loss Total weight loss: 25.3% from baseline 89.5% maintained at least 80% of initial weight loss Switched to Placebo: 14% weight regain Total weight loss: 9.9% from baseline Only 16.6% maintained at least 80% of initial weight loss Key Takeaway: Continued treatment is essential for maintaining weight loss

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"Semaglutide Alleviates Ovary Inflammation via the AMPK/SIRT1/NF-B Signaling Pathway in Polycystic Ovary Syndrome Mice." Drug Design, Development and Therapy , vol

He said the drugs are intended for long-term management of conditions such as type 2 diabetes and obesity, and should only be prescribed after doctors determine they are appropriate as part of a comprehensive care plan