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However, not all studies report increased risk with the Leu allele

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Exon 3 encodes the remaining of the leader peptide and a portion of the mature IGF-I peptide

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GLP-1 Receptor Agonists Reduce Colorectal Cancer Risk in IBD Populations Cancer Network Staff Tim Cortese , Russ Conroy Retrospective data showed that GLP-1 receptor agonist use was associated with a 51% reduction in colorectal cancer odds among patients with inflammatory bowel disease

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