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Specific conditions including G6PD deficiency, oxalate-related kidney conditions, advanced kidney disease, and pregnancy or breastfeeding require careful evaluation before high-dose vitamin C infusions

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Some patients experience increased nausea or diarrhea when exercising shortly after taking metformin

But with MOUs, exceptions to this definition have been made with some agencies

10.2147/ijn.s377600 49 LiangW.ZhouC.DengY.FuL.ZhaoJ.LongH.et al (2024)