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However, a crucial limitation of the above studies is that the endpoint was pathologic (described as asymptomatic chronic pancreatitis), referring to histologic changes, rather than clinical 26

Brett, J

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The combination produced greater weight loss, blunted the weight regain that often follows treatment, sustained glucose control and, notably, helped prevent the muscle (grip-strength) loss seen with the drug alone

Berberine has long been utilized in traditional Chinese and Ayurvedic medicine to treat conditions including inflammation, skin disorders, infections, diabetes, gastrointestinal ailments, and respiratory issues