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Tirzepatide's efficacy is blunted in the presence of ultra-processed, hyper-palatable foods that override satiety signaling

This suggests the release of PYY through neural reflex, possibly mediated by the vagus

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Hepatic histopathology (Fig.4-A, B) showed that both semaglutide and tirzepatide significantly reduced the non-alcoholic fatty liver disease activity score (NAS) by decreasing steatosis and cell ballooning, compared to the non-restricted diet model group