Later doses may seem weaker, throwing off your weight-loss or blood-sugar goals
The intention isnt to achieve maximum appetite suppression immediately, but rather to gently engage the GLP-1 pathway, reduce side effects like nausea and fatigue, and allow the body to adapt
Importantly, this analysis also highlights the drug-specific variability in rebound weight patterns, with GLP-1 receptor agonists, like semaglutide, showing greater initial efficacy but also more pronounced regain when discontinued
Scaling safely takes 26 months
[5] [6] Similarly, individuals with pre-existing fatigue, anaemia, or other comorbidities may find that GLP-1 therapy temporarily exacerbates their symptoms