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There is abundant pre-clinical and clinical evidence implicating the DPP-4-incretin axis in CVD
Scheibye-Knudsen (University of Copenhagen, Denmark), E.F
A low starting point gives your body time to adjust to the dual-receptor activity
As exercise professionals contribute to the holistic care of persons with obesity, they must remain informed of the unique biological, behavioral, and environmental contributors that may be impacting their clients body weight, stay current with AOMs, and develop a comprehensive referral network for when their clients require support (dietary, psychiatric, medical) beyond exercise professionals scope of practice
Dietary Modifications Adjusting your diet can substantially reduce digestive discomfort: Eat smaller, more frequent meals rather than large portions, which accommodates the delayed gastric emptying Reduce dietary fat intake , particularly saturated fats, as these are more difficult to digest when stomach emptying is slowed Avoid spicy, heavily seasoned, or fried foods that may exacerbate nausea or diarrhoea Increase soluble fibre gradually (oats, psyllium, fruits) if experiencing diarrhoea, as this helps bulk stools Stay well hydrated , consuming at least 1.5-2 litres of water daily, especially if experiencing loose stools (note: adjust fluid targets if you have heart failure or chronic kidney diseaseconsult your healthcare provider for personalised advice) Limit alcohol and caffeine , both of which can irritate the digestive system Timing and Dose Escalation According to the BNF and SmPC, Ozempic is initiated at a low dose (0.25 mg weekly) specifically to minimise gastrointestinal side effects
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