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This is noteworthy as these analogues are at least 10-fold less potent then GLP-1-G 2 ( 1 ), meaning that even if at least 10 times more compound is required to get the same activity in vitro, they have a significant longer acting period
constipation, reflux, or intermittent nausea may continue Persistent or progressive symptoms rather than gradual improvement After month 3 Symptoms may remain mild or infrequent at a tolerated regimen New severe symptoms should not automatically be blamed on the medication The most important pattern is not simply "week 1 is bad and month 3 is good." A more accurate pattern is initiation, adaptation, possible symptom flare during dose escalation, and reassessment based on tolerability
Mesa, T., & Munn-Bosch, S
Clin Med Insights Reprod Health
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