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The peptide was first identified in 1973 by Loren Pickart during research on human plasma, where he observed that a small copper-peptide complex was present in younger blood samples at higher concentrations than in older ones

Oxidation of hepatic carnitine palmitoyl transferase-I(CPT-I)impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet

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(2) a bifunctional -glutamylcysteine synthetase/glutathione synthetase (GshF)