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The STEP 1 trial, published in the New England Journal of Medicine, showed that this sustained caloric reduction led to an average weight loss of 14.9% of body weight over 68 weeks

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Twenty-fourhour ambulatory BP was monitored and recorded in a representative subgroup of consenting patients by TM-2430 equipment (A&D Company, Tokyo, Japan) that was set to obtain measurements at 15-minute intervals during daytime (6:00 am to 10:00 pm) and 30-minute intervals during nighttime (10:00 pm to 6:00 am)