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Views on how the impact of these treatments for obesity and diabetes could exceed those projected in our central scenario and the potential for further reductions in mortality and morbidity as the therapeutic landscape for incretin-based drugs expands beyond obesity and diabetes Considerations for how to incorporate these insights into future improvement bases Underwriting and claims considerations Key findings 1

If certain symptoms persist (e.g., sexual dysfunction), switching to an SSRI with a better side effect profile or augmenting with another agent such as bupropion may be considered

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Lower inflammation burden Excess body fat contributes to systemic inflammation