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You dont want to stow it away in a place where it can get overheated, such as your glove compartment, trunk, or checked luggage

Additionally, avoiding carbonated beverages, which can increase gastric pressure, might also reduce the risk

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Indeed, data from STEP-HFpEF and STEP-HFpEF DM trials have shown a significant reduction in inflammatory markers such as CRP with semaglutide compared with placebo 45,46

The clinician should be aware, of course, of the severe CV morbidity burden that DM carries on, and be prepared to prevent heart failure by focusing on its early signs and initiating with SGLT-2 inhibitors particularly in patients at higher CV risk [110, 111]