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Finally, some commonly used drugs (e.g., glucocorticoids and GLP-1RAs) can also affect intra-portal insulin levels that modulate the GH/IGF-I axis either by increasing or decreasing hepatic GH sensitivity, as reflected by the discordant GH and IGF-I levels

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In fact, GLP-1 users risk losing between 40 and 60 percent of their lean mass (which also includes organs, bones, fluids, and even water stored in fat tissue)