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Freeze-drying (called lyophilization) pulls all the water out and locks the peptide into a stable powder that can sit unused for years without losing potency

There is some evidence of a role for topiramate treatment off-label for eating disorders such as binge-eating disorder, for tics due to Tourettes syndrome or other chronic tic disorders, or for substance abuse disorders such as alcohol dependence

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If the needle is too short, the medication may not reach the muscle tissue, resulting in reduced effectiveness