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Average weight loss hides how many people actually hit meaningful thresholds, so the trials also report the share of participants reaching 5%, 10%, 15%, and 20% body-weight reductions

Based on current data predicting liver outcomes by fibrosis stage, patients with stages F2-F4 are considered likely to benefit from antifibrotic medication, often seen as a signal to initiate drug intervention

Muscle is the tissue most responsible for maintaining metabolic health