glp 1 incretin effect PDB-101: Diabetes Mellitus: Diabetes Mellitus: undefined: Incretins Lipotoxicity impairs incretin signalling |

GLP-1 acts through specific receptors found in the pancreas, gastrointestinal tract, and central nervous system to modulate insulin secretion, suppress glucagon, and slow gastric emptying

GLP-1RAs as novel and promising drugs for T2DM, they could stimulate insulin secretion in a glucose-dependent manner, protect cell function, and suppress glucagon secretion (Sharma et al., 2018)

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Large-scale clinical studies are needed before definitive conclusions can be drawn