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In the cytoplasm, Keap1 homodimer forms ubiquitin E3 ligase complex with cullin 3 (Cul3), which polyubiquitinates Nrf2 protein leading to its continuous proteasomal degradation ( Figure 3, right)

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However, adverse effects like nausea and changes in gastric motility are not uncommon, and their persistence over time is still under investigation for laboratory research use only or equivalent

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Human periodontal ligament stem cells cultured onto cortico-cancellous scaffold drive bone regenerative process