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Growth response to rhIGF-I 80 microg/kg twice daily in children with growth hormone insensitivity syndrome: relationship to severity of clinical phenotype
Haase, C
Formula reference (illustrative): doubling_time = ln(2) / ln( V2 / V1 ) * days_between_measurements Example input and output Realistic example: Input: Date 1: 2025-11-20, hCG: 120 mIU/mL Date 2: 2025-11-24, hCG: 480 mIU/mL Output: Doubling time: 2.0 days Percent increase per 48 hours: 300% Estimated gestational age range: about 5 to 6 weeks (clinical confirmation required) Interpretation: hCG is rising rapidly, consistent with early viable pregnancy but clinical correlation is necessary
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