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GPX4 and glutaminase inhibitors can inhibit pyrimidine synthesis and increase ROS levels in VHL-deficient renal carcinoma cells, and the PARP inhibitor olaparib and glutaminase inhibitors can synergistically inhibit the growth of these cells in vivo and in vitro

Alongside these programs, 2026 will bring the launch of new pivotal trials and the continuation of large cardiovascular and oncology studies, even as some late-stage efforts discontinued in 2025 remind us that not every program reaches its goals

PMID: 41995456 J VirolPorcine epidemic diarrhea virus manipulates IMPDH-dependent nucleotide biosynthesis to facilitate replication

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