The members of the MSSG include representatives of EU Member States, one representative of the European Commission, one EMA representative, as well as an observer from EMAs Patients and Consumers Working Party (PCWP) and an observer from EMAs Healthcare Professionals Working Party (HCPWP)
Sudden cutaneous adverse reactions (SCARs) such as Stevens-Johnson Syndrome (SJS), Epidermal Necrolysis (TEN) and Drug reaction with eosinophilia and systemic symptoms (DRESS) and angioedema Summary of Monitoring Baseline tests: BMI, clotting, FBC, LFT, platelet, pregnancy count Ongoing (6 months then annually): BMI, FBC, LFT Prior to surgery / following any bleeding or bruising: Clotting screen, FBC [end-clinical] Interactions Valproate is associated with numerous clinically significant drug interactions due to its effects on hepatic enzyme systems and protein binding
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The peptides plasma half-life is approximately 33 minutes, but tissue retention in central nervous system regions extends the appetite-suppressing effect to 68 hours per administration
