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Can I safely use NAD+ injections at home
Additional considerations include diabetic retinopathy status (semaglutide may worsen retinopathy in some patients with pre-existing disease, particularly with rapid A1c improvement), history of pancreatitis (use GLP-1 agents with caution), and upcoming surgical procedures (discuss with your surgical/anesthesia team due to effects on gastric emptying)
This is particularly relevant as the BBB represents a major challenge in CNS drug delivery, often preventing neurotherapeutic agents from effectively reaching the brain
Feb 7 2024;45(6):419-438
However, it is recommended that it should not be used in patients with active bladder cancer and the benefits of glycemic control versus unknown risks for cancer recurrence with piaglitazone should be weighed in patients with a prior history of bladder cancer
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