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Published online July 31, 2025

Industrial processes

10.1073/pnas.1309078110 97 MayfordM.SiegelbaumS

The most common vitamin B12 deficiency symptoms are: Fatigue Weakness Loss of appetite Weight loss Numbness and tingling in the hands and feet Soreness of the mouth or tongue A pale yellow tinge to your skin Difficulty maintaining balance Disturbed vision Depression Confusion Poor short-term memory A severe vitamin B12 deficiency can cause megaloblastic anemia, also known as vitamin B12 deficiency anemia, where red blood cells are not produced properly and are larger than normal

N-Acetylglucosamine 6-O-sulfotransferase-1 is required for brain keratan sulfate biosynthesis and glial scar formation after brain injury