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Contraindications and cautions include severe gastrointestinal disease, previous pancreatitis, and severe renal impairment (depending on the specific agent)

To understand the difference between these medications, lets start with understanding GLP-1, the general name given to these types of medications: Glucagon-like peptide-1 (GLP-1) is a 30- or 31-amino-acid-long peptide hormone

off-label use should generally be limited to clinical trials or specialist-directed care

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