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At the same time, the authors also found that GSH content in 4T1 cells was sharply cut down owing to Glud-MFo-c GSH-depletion ability (Figure 6C), which effectively amplified Ce6-produced 1 O 2 accumulation, and provided a potential method to combat cancer

To explore whether the reduced ferroptosis sensitivity of NPC cells caused by EBV infection depends on the upregulated expression of GPX4, we used two specific shRNAs to knockdown endogenous GPX4 (Fig

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In addition, metformin decreases susceptibility to seizures, reduces the number and length of seizures, and eliminates the mortality induced by the pro-convulsive agent pentylenetetrazol (PTZ) in Lafora disease mouse models [78]