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Re: systemic therapy for bladder pain syndrome/interstitial cystitis (BPS/IC): systematic review of published trials in the last 5 years

2.2.4 Hepatoprotective Research studies identified the hepatoprotective effect of alogliptin

GHRH upregulates the pituitary-specific POU homeodomain transcription factor, Pit-1, which in turn, transcriptionally upregulates the GH1 , GHRHR and Pit-1 genes (auto-upregulation)

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The FDA recommends using a non-oral contraceptive method or a backup method for 4 weeks after starting tirzepatide and after each dose increase