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These agents act on multiple metabolic pathways, improving insulin sensitivity, reducing body weight, and lowering systemic inflammation, all of which contribute to nerve damage in diabetes

These might include new medicines and ways to stimulate nerves

Experts say testosterone is a critical metabolic hormone that affects energy levels, body composition, and fat loss

Atherosclerosis: the road ahead

For example, ER stress can promote acinar cell apoptosis by activating the p53/AIFM2 axis and the PERKJNK pathway, 252,253,254,264 induce caspase-1-dependent pyroptosis via activation of the PERK pathway, 265 and trigger necroptosis in pancreatic acinar cells by enhancing CTSB maturation and activating the PKCJNKc-Jun cascade