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During the past 5 years, COVID-19, as a magnifying glass of public health problems, posed an unprecedented worldwide challenge and evolved into a sudden public health emergency overnight, which is unparalleled in contemporary history (329, 330)

Dai J, Vrensen GF, Schlingemann RO

Last updated July 22, 2026

Therefore, for comprehensive diagnosis of MNTI, two or three of the above-mentioned markers are combined with the S-100 protein index ( A slow-growing painless tumor mass is characteristically observed in more than half of the patients with primary soft tissue CCS