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The antizyme 1 mRNAs contain two overlapping open reading frames (ORFs)
It follows the same regulatory arc as BPC-157 and TB-500: Category 2 placement in 2023, removal from Category 2 in April 2026, and formal PCAC review scheduled for July 23, 2026
A broadly consistent pattern was observed across agents, characterized by an early peak after treatment initiation, followed by a decline and a modest increase with longer exposure
The relationship remained consistent after adjustment for study duration, baseline body mass index, sex distribution and diabetes status, at 0.36 millimetres of mercury per one per cent weight loss