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Heinzerling L, Ascierto PA, and Dummer R, et al (2019) Adverse events 2.0-Let us get SERIOs: new reporting for adverse event outcomes needed in the era of immunooncology Eur J Cancer 112 2931 PMID: 30903870 77

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Knowler WC, Fowler SE, Hamman RF, Christophi CA, Hoffman HJ, et al

This increase in both intracellular trypsinogen and cathepsin B, an enzyme that can cleave the trypsinogen activation peptide (TAP) from the zymogen to form mature trypsin, results in a premature intrapancreatic activation of trypsin