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For brain-targeting compounds, where the goal is modulating delicate neurotransmitter systems and growth factor pathways, impurities are not just unwanted, they are potentially dangerous

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Similarly, the use of necrostatin-1 to block necroptosis failed to alleviate the H 2 O 2 (500 M, 2 h)-evoked release of LDH (Fig

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The improvement shown in cohort C in achieving the predefined target exposure was statistically significant as compared to cohorts A and B ( Figures 1A, B )