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The concentrations are 140 times higher than in serum, and alterations in GSH metabolism in the lungs are considered central in the context of inflammatory lung diseases [52], [53], [54]

GPX4 plays an important role in mitophagy, the key step of peripheral reticulocyte maturation and GPX4 deficiency in reticulocytes results in a failure to fully mature

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In this demographic, cardiovascular medications and non-steroidal anti-inflammatory drugs (NSAIDs) are frequently employed to manage related conditions, yet they can potentially compromise renal function through mechanisms such as fluid depletion or drug interactions ( AKI following coronary angiography remains a clinically significant concern, particularly in elderly patients

These findings suggest that targeting of GPX4 may represent a therapeutic strategy to prevent acquired drug resistance