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In conclusion, the glutamatergic hypothesis of the mechanism of action of acamprosate helps explain many of its effects in human alcohol dependence and points the way to potential new activities, such as neuroprotection, that merit exploration in the clinic.

[2] [14] Conditions that impair intrinsic factor production such as pernicious anaemia or gastric surgery can lead to deficiency regardless of dietary intake

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Additionally, heterogeneity among the SNPs was assessed using Cochranes Q test