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MOTS-c targets mitochondrial metabolism, Sermorelin stimulates growth hormone release, and CJC-1295/Ipamorelin does the same through a dual-receptor approach

Zhonghua Er Ke Za Zhi 2017;55:135-8

Moreover, the first global genome-wide epigenetic analysis in VAT 211 from IR and insulin-sensitive (IS) morbidly obese patients identified a novel IR-related gene, the zinc finger protein 714 (ZNF714) exhibited the highest DNA methylation difference, and its methylation levels is lower in IR patient than in IS patient, consistent with increased transcription levels, such studies provide potential epigenetic biomarkers related to IR in addition to novel treatment targets for the prevention and treatment of metabolic disorders

References 178 and 179 provide evidence that impaired mitochondrial function may not be a causative factor for insulin resistance

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