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Edge MD, Johnson SL, Ng T, Carver CS
Because the compound's half-life of approximately 30 minutes is short relative to the natural inter-pulse interval of GH secretion (typically 90180 minutes), CJC-1295 No DAC produces discrete GH pulses that mimic the physiological secretory pattern rather than creating sustained GH elevation
Villarroya, F., Peyrou, M
Genomics 2013;102:148-56
As the MSH mimic-induced rescue phenotype occurred in red-haired mice carrying MC1R deficiency (as a result of an e/e Mc1r frameshift mutation), it suggested that an MSH receptor other than MC1R is the likeliest mediator of the altered nociception (and opioid antagonism)
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