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PMCID: PMC6102891

GH IGF-1 downstream anabolic effects GH released by ipamorelin acts on hepatic GH receptors to induce IGF-1 production, which mediates most of the classically "anabolic" effects attributed to GH (protein synthesis, lipolysis, nitrogen retention, bone turnover)

This promotes the progression of PCa by the activation of IGF-1 receptor downstream signaling

Fourth, although the sample size achieved the necessary statistical power to support the results, future studies should include larger sample sizes to analyze cohorts and corroborate the directions of the present findings