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doi: 10.1111/dom.14979 [DOI] [PubMed] [Google Scholar] 15
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CHEMICAL STRUCTURE CAS Number : 2023788-19-2 Molecular Formula : C 225 H 348 N 48 O 68 Molecular Weight : ~4813 Da Molar Mass Structure : Synthetic 39-amino acid peptide Peptide Sequence: His-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Aib-Leu-Asp-Lys-Glu-Glu-Glu-Glu-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH
Tirzepatide, which acts on both GIP and GLP-1 receptors, appears to have a somewhat more favorable GI tolerability profile, possibly because GIP receptor activation partially counteracts the nausea-inducing effects of GLP-1 agonism
The same phenomenon occurs with semaglutide, where weight loss plateaus prompt similar alternative-seeking behavior
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