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Simultaneously, these agents suppress glucagon secretion , a hormone that raises blood glucose, thereby further improving glycaemic control

Additionally, a meta-analysis of various clinical trials, published in the "Journal of Obesity," concluded that GLP-1 receptor agonists were associated with a significant reduction in body weight

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Furthermore, since the GLP-1 receptors are trafficked and inserted into the axon terminal membranes, that may make it difficult to visualize binding, because one is looking at diffuse scattered axon terminals rather than concentrated neuronal cell body labeling