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Behavioral intervention consisted of counseling by a dietitian or similarly qualified healthcare professional every 4 weeks via in-person visits or telephone on adherence to a reduced-calorie diet (500 kcal deficit a day relative to the energy expenditure estimated at randomization) and increased physical activity (150 minutes a week encouraged, for example, walking), both recorded daily (via a diary, app or other tools, which were reviewed during counseling sessions)

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Slower dose escalation is the most effective single strategy for reducing side effects with both medications

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Every batch is HPLC-tested to confirm a purity of 99%, consistent with its GLP-1/GIP/GCGR triple-agonist profile (CAS number 2381089-83-2)